Article
Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes.
Inflammatory bowel diseases - 1 Sept 2003
Brant Steven R, Picco Michael F, Achkar Jean-Paul, Bayless Theodore M, Kane Sunanda V, Brzezinski Aaron, Nouvet Franklin J, Bonen Denise, Karban Amir, Dassopoulos Themistocles, Karaliukas Reda, Beaty Terri H, Hanauer Stephen B, Duerr Richard H, Cho Judy H
Abstract excerpt
BACKGROUND: Multiple factors, particularly IBD family history, tobacco use, age at diagnosis and recently, NOD2 mutant genotypes may influence Crohn's disease (CD) heterogeneity. METHODS: We performed a multicenter retrospective record analysis of 275 unrelated patients with CD. Age at diagnosis, IBD family history, Jewish ethnicity, tobacco use at diagnosis, surgical history, disease site and clinical behavior...
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