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Article

ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017

Chen Chun-Chin, Kass Elizabeth M, Yen Wei-Feng, Ludwig Thomas, Moynahan Mary Ellen, Chaudhuri Jayanta, Jasin Maria

Abstract excerpt

BRCA1 is essential for homology-directed repair (HDR) of DNA double-strand breaks in part through antagonism of the nonhomologous end-joining factor 53BP1. The ATM kinase is involved in various aspects of DNA damage signaling and repair, but how ATM participates in HDR and genetically interacts with BRCA1 in this process is unclear. To investigate this question, we used the Brca1S1598F mouse model carrying a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28659469
DOI: 10.1073/pnas.1706392114
PMCID: PMC5530697

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.PMID 28659469Read ↗

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