Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.

doi:10.1073/pnas.1419502112

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Article

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015

Hasumi Hisashi, Baba Masaya, Hasumi Yukiko, Lang Martin, Huang Ying, Oh HyoungBin F, Matsuo Masayuki, Merino Maria J, Yao Masahiro, Ito Yusuke, Furuya Mitsuko, Iribe Yasuhiro, Kodama Tatsuhiko, Southon Eileen, Tessarollo Lino, Nagashima Kunio, Haines Diana C, Linehan W Marston, Schmidt Laura S

Abstract excerpt

Folliculin (FLCN)-interacting proteins 1 and 2 (FNIP1, FNIP2) are homologous binding partners of FLCN, a tumor suppressor for kidney cancer. Recent studies have revealed potential functions for Flcn in kidney; however, kidney-specific functions for Fnip1 and Fnip2 are unknown. Here we demonstrate that Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. We observed no...

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Identifiers

PMID: 25775561
DOI: 10.1073/pnas.1419502112
PMCID: PMC4386336

Genes

FLCN
FNIP1
FNIP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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