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Article

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin.

Journal of medical genetics - 1 Mar 2010

Hudon V, Sabourin S, Dydensborg A B, Kottis V, Ghazi A, Paquet M, Crosby K, Pomerleau V, Uetani N, Pause A

Abstract excerpt

BACKGROUND: Renal cell carcinoma (RCC) comprises five major molecular and histological subtypes. The Birt-Hogg-Dubé (BHD) syndrome is a hereditary human cancer syndrome that predisposes affected individuals to develop renal carcinoma of nearly all subtypes, in addition to benign fibrofolliculomas, and pulmonary and renal cysts. BHD is caused by loss-of-function mutations in the folliculin (FLCN) protein. The...

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Source

Identifiers

PMID: 19843504
DOI: 10.1136/jmg.2009.072009

Genes

FLCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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