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Article

Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

18 Jan 2021

Abstract excerpt

Germline mutations in the Folliculin ( FLCN ) tumor suppressor gene cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney tumors. FLCN is a conserved, essential gene linked to diverse cellular processes but the mechanism by which FLCN prevents kidney cancer remains unknown. Here, we show that disrupting FLCN in human renal tubular epithelial cells (RPTEC/TERT1)...

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PMID: 33459596
DOI: 10.7554/elife.61630

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