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Article

Estimation of genetic risk function with covariates in the presence of missing genotypes.

Statistics in medicine - 30 Sept 2017

Lee Annie J, Marder Karen, Alcalay Roy N, Mejia-Santana Helen, Orr-Urtreger Avi, Giladi Nir, Bressman Susan, Wang Yuanjia

Abstract excerpt

In genetic epidemiological studies, family history data are collected on relatives of study participants and used to estimate the age-specific risk of disease for individuals who carry a causal mutation. However, a family member's genotype data may not be collected because of the high cost of in-person interview to obtain blood sample or death of a relative. Previously, efficient nonparametric genotype-specific...

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PMID: 28656686
DOI: 10.1002/sim.7376
PMCID: PMC5583003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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