Article
A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence.
mBio - 27 Jun 2017
Zhang Jianhua, Snelders Eveline, Zwaan Bas J, Schoustra Sijmen E, Meis Jacques F, van Dijk Karin, Hagen Ferry, van der Beek Martha T, Kampinga Greetje A, Zoll Jan, Melchers Willem J G, Verweij Paul E, Debets Alfons J M
Abstract excerpt
This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed. After heat shock, to which sexual but not asexual spores are highly resistant, the azole-free compost yielded 98% (49/50) wild-type and 2% (1/50) azole-resistant isolates, whereas the azole-containing compost yielded 9% (4/45) wild-type and...
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