Article
Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma.
Journal of molecular cell biology - 1 Dec 2017
Li Meiyi, Li Chen, Liu Wei-Xin, Liu Conghui, Cui Jingru, Li Qingrun, Ni Hong, Yang Yingcheng, Wu Chaochao, Chen Chunlei, Zhen Xing, Zeng Tao, Zhao Mujun, Chen Lei, Wu Jiarui, Zeng Rong, Chen Luonan
Abstract excerpt
Little is known about how chronic inflammation contributes to the progression of hepatocellular carcinoma (HCC), especially the initiation of cancer. To uncover the critical transition from chronic inflammation to HCC and the molecular mechanisms at a network level, we analyzed the time-series proteomic data of woodchuck hepatitis virus/c-myc mice and age-matched wt-C57BL/6 mice using our dynamical network...
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