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Article

PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma.

Oncotarget - 11 Jul 2017

Murnyák Balázs, Kouhsari Mahan C, Hershkovitch Rotem, Kálmán Bernadette, Marko-Varga György, Klekner Álmos, Hortobágyi Tibor

Abstract excerpt

Overexpression of PARP1 exists in various cancers, including glioblastoma (GBM). Although PARP1 inhibition is a promising therapeutic target, no comprehensive study has addressed PARP1's expression characteristics and prognostic role regarding molecular heterogeneity in astrocytomas including GBM. Our aim was to evaluate PARP1's associations with survival, WHO grade, lineage specific markers, and GBM...

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Source

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Identifiers

PMID: 28654422
DOI: 10.18632/oncotarget.18013
PMCID: PMC5542272

Genes

PARP1
ATRX
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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