Article
A simplified approach for molecular classification of glioblastomas (GBMs): experience from a tertiary care center in India.
Brain tumor pathology - 1 Jul 2016
Purkait Suvendu, Mallick Supriya, Sharma Vikas, Kumar Anupam, Pathak Pankaj, Jha Prerana, Biswas Ahitagni, Julka Pramod Kumar, Gupta Deepak, Suri Ashish, Upadhyay Ashish Datt, Suri Vaishali, Sharma Mehar C, Sarkar Chitra
Abstract excerpt
This study aims to establish a simplified molecular classification of glioblastomas (GBMs) based on molecular genetic alterations. GBM cases (n-114) were evaluated for IDH-1 and TP53 mutation by Sanger sequencing, PDGFRA and EGFR amplification by FISH, NF1 and YKL40 expression by qRT-PCR. Subsequently they were classified into four subgroups: classical like (CL), proneural like (PN), mesenchymal like (MES) and...
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