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Article

Therapeutic Application of PARP Inhibitors in Neuro-Oncology.

Trends in cancer - 1 Feb 2020

Ning Jianfang, Wakimoto Hiroaki

Abstract excerpt

In response to a variety of cellular stresses, poly(ADP-ribose) polymerase 1 (PARP1) has vital roles in orchestrating DNA damage repair and preserving genomic integrity. Clinical activity of PARP inhibitors (PARPis) in BRCA1/2 mutant cancers validated the concept of synthetic lethality between PARP inhibition and deleterious BRCA1/2 mutations, leading to clinical approval of several PARPis. Preclinical and...

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Identifiers

PMID: 32061304
DOI: 10.1016/j.trecan.2019.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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