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Article

PARP-1 protein expression in glioblastoma multiforme

27 Feb 2012

Abstract excerpt

One of the most common type of primary brain tumors in adults is the glioblastoma multiforme (GBM) (World Health Organization grade IV astrocytoma). It is the most common malignant and aggressive form of glioma and it is among the most lethal ones. Poly (ADP-ribose) polymerase 1 (PARP-1) gene, located to 1q42, plays an important role for the efficient maintenance of genome integrity. PARP-1 protein is required...

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PMID: 22472897
DOI: 10.4081/ejh.2012.e9

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