Article
Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide.
International journal of chronic obstructive pulmonary disease - 1 Jan 2017
Blanco Ignacio, Bueno Patricia, Diego Isidro, Pérez-Holanda Sergio, Lara Beatriz, Casas-Maldonado Francisco, Esquinas Cristina, Miravitlles Marc
Abstract excerpt
The alpha-1 antitrypsin (AAT) haplotype Pi*S, when inherited along with the Pi*Z haplotype to form a Pi*SZ genotype, can be associated with pulmonary emphysema in regular smokers, and less frequently with liver disease, panniculitis, and systemic vasculitis in a small percentage of people, but this connection is less well established. Since the detection of cases can allow the application of preventive measures...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.