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Article

Alpha-1 antitrypsin PiZ gene frequency and PiZZ genotype numbers worldwide: an update.

International journal of chronic obstructive pulmonary disease - 1 Jan 2017

Blanco Ignacio, Bueno Patricia, Diego Isidro, Pérez-Holanda Sergio, Casas-Maldonado Francisco, Esquinas Cristina, Miravitlles Marc

Abstract excerpt

In alpha-1 antitrypsin deficiency (AATD), the Z allele is present in 98% of cases with severe disease, and knowledge of the frequency of this allele is essential from a public health perspective. However, there is a remarkable lack of epidemiological data on AATD worldwide, and many of the data currently used are outdated. Therefore, the objective of this study was to update the knowledge of the frequency of the...

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Identifiers

PMID: 28243076
DOI: 10.2147/COPD.S125389
PMCID: PMC5315200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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