Article
Causal Genetic Variation Underlying Metabolome Differences.
Genetics - 1 Aug 2017
Swain-Lenz Devjanee, Nikolskiy Igor, Cheng Jiye, Sudarsanam Priya, Nayler Darcy, Staller Max V, Cohen Barak A
Abstract excerpt
An ongoing challenge in biology is to predict the phenotypes of individuals from their genotypes. Genetic variants that cause disease often change an individual's total metabolite profile, or metabolome. In light of our extensive knowledge of metabolic pathways, genetic variants that alter the metabolome may help predict novel phenotypes. To link genetic variants to changes in the metabolome, we studied natural...
Topics
- Genetic Variation
- Genotype
- Metabolome
- Phenotype
- Quantitative Trait Loci
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Urea