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Article

Evolutionary dynamics and significance of multiple subclonal mutations in cancer.

DNA repair - 1 Aug 2017

Beckman Robert A, Loeb Lawrence A

Abstract excerpt

For the last 40 years the authors have collaborated on trying to understand the complexities of human cancer by formulating testable mathematical models that are based on mutation accumulation in human malignancies. We summarize the concepts encompassed by multiple mutations in human cancers in the context of source, accumulation during carcinogenesis and tumor progression, and therapeutic consequences. We...

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Identifiers

PMID: 28652129
DOI: 10.1016/j.dnarep.2017.06.002
PMCID: PMC5551892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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