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Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus

25 Jun 2017

Abstract excerpt

Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. It has shown promise as a cancer therapeutic in preclinical studies and early-phase clinical trials. Here, we have identified anthrax toxin receptor 1 (ANTXR1) as the receptor for SVV using genome-wide loss-of-function screens. ANTXR1 is necessary for permissivity in vitro and in vivo. However, robust SVV...

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PMID: 28650343
DOI: 10.1172/jci93472

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