Article
Lrrk2 mutations in South America: A study of Chilean Parkinson's disease.
Neuroscience letters - 18 Jul 2007
Perez-Pastene Carolina, Cobb Stephanie A, Díaz-Grez Fernando, Hulihan Mary M, Miranda Marcelo, Venegas Pablo, Godoy Osvaldo Trujillo, Kachergus Jennifer M, Ross Owen A, Layson Luis, Farrer Matthew J, Segura-Aguilar Juan
Abstract excerpt
Pathogenic substitutions in the leucine-rich repeat kinase 2 protein (Lrrk2), R1441G and G2019S, are a prevalent cause of autosomal dominant and sporadic Parkinson's disease in the Northern Spanish population. In this study we examined the frequency of these two substitutions in 166 Parkinson's d...
Topics
- Age of Onset
- Chile
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Polymerase Chain Reaction