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Article

Lrrk2 mutations in South America: A study of Chilean Parkinson's disease.

Neuroscience letters - 18 Jul 2007

Perez-Pastene Carolina, Cobb Stephanie A, Díaz-Grez Fernando, Hulihan Mary M, Miranda Marcelo, Venegas Pablo, Godoy Osvaldo Trujillo, Kachergus Jennifer M, Ross Owen A, Layson Luis, Farrer Matthew J, Segura-Aguilar Juan

Abstract excerpt

Pathogenic substitutions in the leucine-rich repeat kinase 2 protein (Lrrk2), R1441G and G2019S, are a prevalent cause of autosomal dominant and sporadic Parkinson's disease in the Northern Spanish population. In this study we examined the frequency of these two substitutions in 166 Parkinson's disease patients and 153 controls from Chile, a population with Spanish/European-Amerindian admixture. Lrrk2 R1441G was...

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Identifiers

PMID: 17614198
DOI: 10.1016/j.neulet.2007.06.021
PMCID: PMC1986707

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Source receipt: pubmed, retrieved 7 Sept 2026.

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