Article
Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine.
Cell host & microbe - 11 Jul 2018
Coughlan Lynda, Palese Peter
Abstract excerpt
Influenza viruses are important pathogens which pose an ongoing threat to public health due to their ability to mutate and evade immunity elicited by prior infection or vaccination. Their evolutionary diversity is facilitated by the plasticity of the antigenically variable head domain of the major surface glycoprotein, hemagglutinin (HA), which tolerates the accumulation of extensive mutations. To date, vaccines...
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