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Article

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

17 Aug 2011

Abstract excerpt

Down syndrome (DS) results from trisomy of human chromosome 21 (Hsa21) and is associated with an increased risk of Alzheimer's disease (AD). Here, using the unique transchromosomic Tc1 mouse model of DS we investigate the influence of trisomy of Hsa21 on the protein tau, which is hyperphosphorylated in Alzheimer's disease. We show that in old, but not young, Tc1 mice increased phosphorylation of tau occurs at a...

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PMID: 21843906
DOI: 10.1016/j.neurobiolaging.2011.06.025

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