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Article

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

28 May 2008

Abstract excerpt

ABSTRACT Adults with Down syndrome (DS) develop Alzheimer neurofibrillary degeneration in the brain, but the underlying molecular mechanism is unknown. Here, we report that the presence of an extra copy of the dual‐specificity tyrosine‐phosphorylated and regulated kinase 1A ( Dyrk1A ) gene due to trisomy 21 resulted in overexpression of Dyrk1A and elevated kinase activity in DS brain. Dyrk1A phosphorylated tau at...

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PMID: 18509201
DOI: 10.1096/fj.07-104539

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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndromePMID 18509201Read ↗

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Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Enhances Tau ExpressionSemantic proximity Read ↗

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.Semantic proximity Read ↗

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