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Article

Direct circulating tumor DNA detection from unpurified plasma using a digital PCR platform.

Clinical biochemistry - 1 Nov 2017

Sefrioui David, Beaussire Ludivine, Perdrix Anne, Clatot Florian, Michel Pierre, Frebourg Thierry, Di Fiore Frédéric, Sarafan-Vasseur Nasrin

Abstract excerpt

BACKGROUND: In standard pre-analytical conditions, an isolation step is required for circulating tumor DNA (ctDNA) analysis. The need for this step remains unclear with the development of ultrasensitive detection technologies such as digital PCR (dPCR). The aim of our study was to evaluate the ctDNA detection by dPCR platform either directly from plasma (plasma group, PG) or after an isolation step (isolation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28645720
DOI: 10.1016/j.clinbiochem.2017.06.005

Genes

MAF
BRAF
KRAS
NRAS

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