Article
Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers.
PloS one - 1 Jan 2017
Zhang Yuchen, Boxberger Kelli H, Hagenbuch Bruno
Abstract excerpt
OATP1B3 is a 12 transmembrane domain protein expressed at the basolateral membrane of human hepatocytes where it mediates the uptake of numerous drugs and endogenous compounds. Previous western blot results suggest the formation of OATP1B3 multimers. In order to better understand the function of OATP1B3 under normal physiological conditions, we investigated its oligomerization status. We transiently transfected...
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