Article
Evidence for dimerization of ferroportin in a human hepatic cell line using proximity ligation assays.
Bioscience reports - 29 May 2020
Rishi Gautam, Secondes Eriza S, Wallace Daniel F, Subramaniam V Nathan
Abstract excerpt
Mutations in the only known iron exporter ferroportin (FPN) in humans are associated with the autosomal dominantly inherited iron overload disorder ferroportin disease or type IV hereditary hemochromatosis (HH). While our knowledge of the central role of FPN in iron homeostasis has grown in the last 20 years, there exist some questions surrounding the structure and membrane topology of FPN with conflicting data...
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