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Article

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α.

PloS one - 1 Jan 2017

Latorre Pedro, Varona Luis, Burgos Carmen, Carrodeguas José A, López-Buesa Pascual

Abstract excerpt

PGC1α is a coactivator of many transcription factors and cytosolic phosphoenolpyruvate carboxykinase (PCK1) is a key enzyme for gluconeogenesis. PGC1α interacts with the transcription factor PPARγ to stimulate PCK1 expression and thus de novo glucose synthesis. These proteins are not only important for central energy metabolism but also for supplying intermediates for other metabolic pathways, including...

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Share to Glucose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Phosphoenolpyruvate Carboxykinase (GTP)

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Source

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Identifiers

PMID: 28644880
DOI: 10.1371/journal.pone.0179988
PMCID: PMC5482481

Genes

PCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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