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Article

O-Linked N-acetylglucosaminylation of Sp1 interferes with Sp1 activation of glycolytic genes.

Biochemical and biophysical research communications - 1 Jan 2000

Lim Kihong, Yoon Bo Hyun, Ha Chang Hoon

Abstract excerpt

Glycolysis, the primary pathway metabolizing glucose for energy production, is connected to the hexosamine biosynthetic pathway (HBP) which produces UDP-N-acetylglucosamine (UDP-GlcNAc), a GlcNAc donor for O-linked GlcNAc modification (O-GlcNAc), as well as for traditional elongated glycosylation. Thus, glycolysis and O-GlcNAc are intimately associated. The present study reports the transcriptional activation of...

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Source

Identifiers

PMID: 26499076
DOI: 10.1016/j.bbrc.2015.10.096

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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