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Article

c.A2456C-substitution in Pck1 changes the enzyme kinetic and functional properties modifying fat distribution in pigs.

Scientific reports - 21 Jan 2016

Latorre Pedro, Burgos Carmen, Hidalgo Jorge, Varona Luis, Carrodeguas José Alberto, López-Buesa Pascual

Abstract excerpt

Cytosolic phosphoenolpyruvate carboxykinase, PCK1, is one of the main regulatory enzymes of gluconeogenesis and glyceroneogenesis. The substitution of a single amino acid (Met139Leu) in PCK1 as a consequence of a single nucleotide polymorphism (SNP), c.A2456C, is associated in the pig to a negative phenotype characterized by reduced intramuscular fat content, enhanced backfat thickness and lower meat quality. The...

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Identifiers

PMID: 26792594
DOI: 10.1038/srep19617
PMCID: PMC4726144

Genes

PCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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