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Article

MDM 2 is implicated in high‐glucose‐induced podocyte mitotic catastrophe via Notch1 signalling

23 Jun 2017

Abstract excerpt

Podocyte injury and depletion are essential events involved in the pathogenesis of diabetic nephropathy (DN). As a terminally differentiated cell, podocyte is restricted in 'post-mitosis' state and unable to regenerate. Re-entering mitotic phase will cause podocyte disastrous death which is defined as mitotic catastrophe (MC). Murine double minute 2 (MDM2), a cell cycle regulator, is widely expressed in renal...

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PMID: 28643424
DOI: 10.1111/jcmm.13253

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