Article
Boundary of the nucleotide-binding domain of Streptococcus ComA based on functional and structural analysis.
Biochemistry - 16 Apr 2013
Ishii Seiji, Yano Takato, Okamoto Akihiro, Murakawa Takeshi, Hayashi Hideyuki
Abstract excerpt
The ATP-binding cassette (ABC) transporter ComA is a key molecule essential for the first step of the quorum-sensing system of Streptococcus. The nucleotide binding domains (NBD) of Streptococcus mutans ComA with different N termini, NBD1 (amino acid residues 495-760), NBD2 (517-760), and NBD3 (528-760), were expressed, purified, and characterized. The shortest NBD3 corresponds to the region commonly defined as...
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