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Article

Anti-GITR Antibody Treatment Increases TCR Repertoire Diversity of Regulatory but not Effector T Cells Engaged in the Immune Response Against B16 Melanoma.

Archivum immunologiae et therapiae experimentalis - 1 Dec 2017

Scirka Bozena, Szurek Edyta, Pietrzak Maciej, Rempala Grzegorz, Kisielow Pawel, Ignatowicz Leszek, Miazek Arkadiusz

Abstract excerpt

Crosslinking of glucocorticoid-induced TNF family-related receptor (GITR) with agonist antibodies restores cancer immunity by enhancing effector T cell (Teff) responses while interfering with intra-tumor regulatory T cell (Treg) stability and/or accumulation. However, how anti-GITR antibody infusion changes T cell receptor (TCR) repertoire of Teffs and Tregs engaged in anti-tumor immune response is unclear. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28638937
DOI: 10.1007/s00005-017-0479-1
PMCID: PMC5688217

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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