Article
Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts.
Thorax - 1 Nov 2017
Castaldi Peter J, Benet Marta, Petersen Hans, Rafaels Nicholas, Finigan James, Paoletti Matteo, Marike Boezen H, Vonk Judith M, Bowler Russell, Pistolesi Massimo, Puhan Milo A, Anto Josep, Wauters Els, Lambrechts Diether, Janssens Wim, Bigazzi Francesca, Camiciottoli Gianna, Cho Michael H, Hersh Craig P, Barnes Kathleen, Rennard Stephen, Boorgula Meher Preethi, Dy Jennifer, Hansel Nadia N, Crapo James D, Tesfaigzi Yohannes, Agusti Alvar, Silverman Edwin K, Garcia-Aymerich Judith
Abstract excerpt
BACKGROUND: COPD is a heterogeneous disease, but there is little consensus on specific definitions for COPD subtypes. Unsupervised clustering offers the promise of 'unbiased' data-driven assessment of COPD heterogeneity. Multiple groups have identified COPD subtypes using cluster analysis, but there has been no systematic assessment of the reproducibility of these subtypes. OBJECTIVE: We performed clustering...
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