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Article

F-actin prevents interaction between sperm DNA and the oocyte meiotic spindle in C. elegans.

The Journal of cell biology - 7 Aug 2017

Panzica Michelle T, Marin Harold C, Reymann Anne-Cecile, McNally Francis J

Abstract excerpt

Fertilization occurs during female meiosis in most animals, which raises the question of what prevents the sperm DNA from interacting with the meiotic spindle. In this study, we find that Caenorhabditis elegans sperm DNA stays in a fixed position at the opposite end of the embryo from the meiotic spindle while yolk granules are transported throughout the embryo by kinesin-1. In the absence of F-actin, the sperm...

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Identifiers

PMID: 28637747
DOI: 10.1083/jcb.201702020
PMCID: PMC5551714

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