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Article

p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome.

Molecular cancer therapeutics - 1 Apr 2005

Nakase Minoru, Inui Madoka, Okumura Kenya, Kamei Takahiko, Nakamura Shinnosuke, Tagawa Toshiro

Abstract excerpt

Gene delivery via transferrin receptors, which are highly expressed by cancer cells, can be used to enhance the effectiveness of gene therapy for cancer. In this study, we examined the efficacy of p53 gene therapy in human osteosarcoma (HOSM-1) cells derived from the oral cavity using a cationic liposome supplemented with transferrin. HOSM-1 cells were exposed to transferrin-liposome-p53 in vitro, and the growth...

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Identifiers

PMID: 15827336
DOI: 10.1158/1535-7163.MCT-04-0196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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