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Article

High Prevalence of Potential Molecular Therapeutic Targets in Poorly Differentiated Thyroid Carcinoma.

Endocrine pathology - 22 Oct 2025

Zambelli Vanessa, Orlando Giulia, Fornaro Marta, Vocino Trucco Giulia, Rapa Ida, Napoli Francesca, Cappia Susanna, Daniele Lorenzo, Piana Simonetta, Papotti Mauro, Volante Marco

Abstract excerpt

Poorly differentiated thyroid carcinoma (PDTC) is a rare thyroid cancer with aggressive clinical course and peculiar clinical/pathological characteristics but lacking effective therapeutic options, when surgery is not curative. We aimed at the molecular characterization of PDTC with a specific focus on the identification of potential therapeutic targets. A series of PDTC cases was selected from a...

Read the complete abstract on PubMed

Topics

Humans
Thyroid Neoplasms
Male
Female
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Mutation

Molecular Targeted Therapy

Aged, 80 and over

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 41123735
DOI: 10.1007/s12022-025-09883-y
PMCID: PMC12546271

Genes

NRAS
TP53
PIK3CA
PTEN
TBL1XR1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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