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Article

NOD2 Genetic Variants Predispose One of Two Familial Adenomatous Polyposis Siblings to Pouchitis Through Microbiome Dysbiosis.

Journal of Crohn's & colitis - 27 Oct 2017

Schieffer Kathleen M, Wright Justin R, Harris Leonard R, Deiling Sue, Yang Zhaohai, Lamendella Regina, Yochum Gregory S, Koltun Walter A

Abstract excerpt

BACKGROUND AND AIMS: Individuals with familial adenomatous polyposis (FAP) may undergo a total proctocolectomy with ileal pouch-anal anastomosis (IPAA) to surgically treat their disease. Inflammation of the ileal pouch, termed pouchitis, is uncommon in FAP patients but prevalent in patients who received IPAA for ulcerative colitis, a type of inflammatory bowel disease (IBD). METHODS AND RESULTS: We report on two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28633443
DOI: 10.1093/ecco-jcc/jjx083
PMCID: PMC5881696

Genes

FAP
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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