Article
Identification of DPB1 Permissive Unrelated Donors Is Highly Likely.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jan 2017
Tram Kevin, Stritesky Gretta, Wadsworth Kim, Ng Jennifer, Anasetti Claudio, Dehn Jason
Abstract excerpt
HLA-DPB1 permissive matching based on T cell epitope (TCE) groups should be considered when selecting among equally matched HLA-A, -B, -C, -DRB1 unrelated hematopoietic stem cell donors to improve patient survival. Previous studies have defined 3 TCE groups based on functional assays of alloreactivity. Combinations of donor and recipient DPB1 alleles with low immunogenic potential identify permissive donors, who...
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