Article
De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance.
Antimicrobial agents and chemotherapy - 1 Sept 2017
Jiménez-Ortigosa Cristina, Perez Winder B, Angulo David, Borroto-Esoda Katyna, Perlin David S
Abstract excerpt
SCY-078 is an orally active antifungal whose target is the β-(1,3)-d-glucan synthase (GS). We evaluated the spontaneous emergence of SCY-078-resistant Candida glabrata isolates following drug exposure in vitro Resistant isolates were analyzed using broth microdilution methodology and FKS sequencing. The kinetic inhibition parameter IC50 (50% inhibitory concentration) was also determined from GS complexes. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.