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Article

Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells.

The Journal of biological chemistry - 1 Sept 2017

Wallin Hanna, Apelqvist Jenny, Andersson Freddi, Ekström Ulf, Abrahamson Magnus

Abstract excerpt

The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhibitor cystatin C is internalized by some cancer cells, which affects cellular properties. Here we aimed to investigate if uptake of cystatin C and the related inhibitor cystatin E/M occur in melanoma cell lines and to evaluate to what extent the uptake affects the legumain activity that is typically increased in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28630039
DOI: 10.1074/jbc.M117.776138
PMCID: PMC5582836

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