Article
Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells.
Oncogene - 18 Mar 2004
Shridhar Ravi, Zhang Jun, Song Jin, Booth Blake A, Kevil Christopher G, Sotiropoulou Georgia, Sloane Bonnie F, Keppler Daniel
Abstract excerpt
Proteases are involved in many aspects of tumor progression, including cell survival and proliferation, escape from immune surveillance, cell adhesion and migration, remodeling and invasion of the extracellular matrix. Several lysosomal cysteine proteases have been cloned and shown to be overexpressed in cancer; yet, despite the great potential for development of novel therapeutics, we still know little about the...
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