Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.

BMC cancer - 19 Jun 2017

Huynh Nhi, Wang Kai, Yim Mildred, Dumesny Chelsea J, Sandrin Mauro S, Baldwin Graham S, Nikfarjam Mehrdad, He Hong

Abstract excerpt

BACKGROUND: P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. The aim of this study was to investigate the effect of PAK1 depletion and inhibition on the immune system and on intestinal tumour formation in APC∆14/+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, APC
Share to Immune System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunomodulation

Share to Leukocyte Count

Share to p21-Activated Kinases

Share to Polycomb Repressive Complex 1

Share to Pyrazoles

Share to Pyrroles

Source

Open in PubMed Open full text

Identifiers

PMID: 28629331
DOI: 10.1186/s12885-017-3432-0
PMCID: PMC5477105

Genes

APC
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.PMID 28629331Read ↗

Inhibition of P21-activated kinases 1 and 4 synergistically suppress the growth of pancreatic cancer by stimulating anti-tumour immunitySemantic proximity Read ↗

PAK1 promotes intestinal tumor initiation.Semantic proximity Read ↗

Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer.Semantic proximity Read ↗

TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.Semantic proximity Read ↗

Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells.Semantic proximity Read ↗

Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.Semantic proximity Read ↗

Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4Semantic proximity Read ↗

Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.Semantic proximity Read ↗

Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.Semantic proximity Read ↗

p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse.Semantic proximity Read ↗

CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in <i>ApcMin/+</i> MiceSemantic proximity Read ↗

Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.