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Article

MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia.

Pharmacogenetics and genomics - 1 Nov 2016

Iparraguirre Leire, Gutierrez-Camino Angela, Umerez Maitane, Martin-Guerrero Idoia, Astigarraga Itziar, Navajas Aurora, Sastre Ana, Garcia de Andoin Nagore, Garcia-Orad Africa

Abstract excerpt

OBJECTIVES: Methotrexate (MTX), the key drug in childhood B-cell acute lymphoblastic leukemia (B-ALL) therapy, often causes toxicity. An association between genetic variants in MTX transport genes and toxicity has been found. It is known that these transporters are regulated by microRNAs (miRNAs), and miRNA single nucleotide polymorphisms (SNPs) interfere with miRNA levels or function. With regard to B-cell ALL,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27649261
DOI: 10.1097/FPC.0000000000000245

Genes

ABCC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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