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Article

Comprehensive Analysis of EGFR-Mutant Abundance and Its Effect on Efficacy of EGFR TKIs in Advanced NSCLC with EGFR Mutations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2017

Li Xuefei, Cai Weijing, Yang Guohua, Su Chunxia, Ren Shengxiang, Zhao Chao, Hu Rongjun, Chen Xiaoxia, Gao Guanghui, Guo Zhiwei, Li Wei, Zhou Caicun, Hirsch Fred R

Abstract excerpt

INTRODUCTION: A qualitative detection method for EGFR mutations is not sufficient to guide precise targeted therapy in clinical practice. The aim of this study was to explore the relationship between the abundance of EGFR mutations and efficacy of EGFR tyrosine kinase inhibitors (TKIs). METHODS: We used the amplification refractory mutation system (ARMS) method optimized with competitive blockers and specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28624467
DOI: 10.1016/j.jtho.2017.06.006

Genes

EGFR

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