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Article

Mutation abundance affects the efficacy of EGFR tyrosine kinase inhibitor readministration in non-small-cell lung cancer with acquired resistance.

Medical oncology (Northwood, London, England) - 1 Jan 2014

Zhao Ze-Rui, Wang Jin-Feng, Lin Yong-Bin, Wang Fang, Fu Sha, Zhang Shu-Lin, Su Xiao-Dong, Jiang Long, Zhang Yi-Gong, Shao Jian-Yong, Long Hao

Abstract excerpt

There is no consensus in the salvage treatment for non-small-cell lung cancer (NSCLC) with acquired resistance to primary epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Fifty-one consecutive EGFR-mutated NSCLC patients with TKI retreatment after acquired resistance were enrolled in this study. The quantitation of mutation abundance was performed by real-time fluorescent quantitative PCR....

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PMID: 24338271
DOI: 10.1007/s12032-013-0810-6

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EGFR

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