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Article

Mutation abundance affects the therapeutic efficacy of EGFR-TKI in patients with advanced lung adenocarcinoma: A retrospective analysis.

Cancer biology & therapy - 3 Aug 2018

Wang Huijuan, Zhang Mina, Tang Wanyu, Ma Jie, Wei Bing, Niu Yuanyuan, Zhang Guowei, Li Peng, Yan Xiangtao, Ma Zhiyong

Abstract excerpt

PURPOSE: To investigate the influence of mutation abundance and sites of epidermal growth factor receptor (EGFR) on therapeutic efficacies of EGFR-tyrosine kinase inhibitor (EGFR-TKIs) treatments of patients with advanced non-small cell lung carcinoma (NSCLC). METHODS: EGFR mutational sites and mutation abundance were analyzed by amplification refractory mutation system (ARMS) in paraffin-embedded tissue sections...

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Identifiers

PMID: 29565727
DOI: 10.1080/15384047.2018.1450115
PMCID: PMC6067862

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EGFR

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