Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.

doi:10.1186/s13075-017-1345-6

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Article

Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.

Arthritis research & therapy - 15 Jun 2017

Aterido Adrià, Julià Antonio, Carreira Patricia, Blanco Ricardo, López-Longo José Javier, Venegas José Javier Pérez, Olivé Àlex, Andreu José Luís, Aguirre-Zamorano Maria Ángeles, Vela Paloma, Nolla Joan M, Marenco-de la Fuente José Luís, Zea Antonio, Pego José María, Freire Mercedes, Díez Elvira, López-Lasanta María, López-Corbeto Mireia, Palau Núria, Tortosa Raül, Gelpí Josep Lluís, Absher Devin, Myers Richard M, Fernández-Nebro Antonio, Marsal Sara

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a genetic basis for SLE heterogeneity. The objective of the present study was to identify new genetic variation associated with the clinically relevant phenotypes in SLE. METHODS: A two-stage...

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PMID: 28619073
DOI: 10.1186/s13075-017-1345-6
PMCID: PMC5471877

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PTPN22

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