Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumour heterogeneity poses a significant challenge to cancer biomarker research

15 Jun 2017

Abstract excerpt

BACKGROUND: The high degree of genomic diversity in cancer represents a challenge for identifying objective prognostic markers. We aimed to examine the extent of tumour heterogeneity and its effect on the evaluation of a selected prognostic marker using prostate cancer as a model. METHODS: We assessed Gleason Score (GS), DNA ploidy status and phosphatase and tensin homologue (PTEN) expression in radical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28618431
DOI: 10.1038/bjc.2017.171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumour heterogeneity poses a significant challenge to cancer biomarker researchPMID 28618431Read ↗

Biomarkers Associated with Tumor Heterogeneity in Prostate CancerSemantic proximity Read ↗

Patterns of intra- and intertumor phenotypic heterogeneity in lethal prostate cancer.Semantic proximity Read ↗

Experimental challenges to modeling prostate cancer heterogeneity.Semantic proximity Read ↗

The Heterogeneity of Prostate Cancer: A Practical ApproachSemantic proximity Read ↗

Impact of tumor heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis.Semantic proximity Read ↗

Exome sequencing of prostate cancer supports the hypothesis of independent tumour origins.Semantic proximity Read ↗

Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signaturesSemantic proximity Read ↗

Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of heterogeneity on genomic signature scoringSemantic proximity Read ↗

Uncovering phenotypic heterogeneity through research autopsy in lethal prostate cancer.Semantic proximity Read ↗

Heterogeneity of miRNA expression in localized prostate cancer with clinicopathological correlationsSemantic proximity Read ↗

PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade.Semantic proximity Read ↗

Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.