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Article

Impact of tumor heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis.

Journal of clinical epidemiology - 1 Oct 2020

Swift Stephanie L, Duffy Steve, Lang Shona H

Abstract excerpt

OBJECTIVE: The objective of the study was to identify guidelines to assist systematic reviewers or clinical researchers in identifying sampling bias due to tumor heterogeneity (TH) in solid cancers assayed for somatic mutations. We also assessed current reporting standards to determine the impact of TH on sample bias. STUDY DESIGN AND SETTING: We conducted a systematic review searching 13 databases (to January...

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Identifiers

PMID: 32540382
DOI: 10.1016/j.jclinepi.2020.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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