Article
Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas.
Familial cancer - 1 Jan 2018
Clendenning Mark, Huang Alvin, Jayasekara Harindra, Lorans Marie, Preston Susan, O'Callaghan Neil, Pope Bernard J, Macrae Finlay A, Winship Ingrid M, Milne Roger L, Giles Graham G, English Dallas R, Hopper John L, Win Aung K, Jenkins Mark A, Southey Melissa C, Rosty Christophe, Buchanan Daniel D
Abstract excerpt
In colorectal cancers (CRCs) with tumour mismatch repair (MMR) deficiency, genes involved in the host immune response that contain microsatellites in their coding regions, including beta-2-microglobulin (B2M), can acquire mutations that may alter the immune response, tumour progression and prognosis. We screened the coding microsatellites within B2M for somatic mutations in MMR-deficient CRCs and adenomas to...
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