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Article

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3.

Scientific reports - 14 Jun 2017

Chen Andy, Wang Luqi, Li Bai-Yan, Sherman Jesse, Ryu Jong E, Hamamura Kazunori, Liu Yunlong, Nakshatri Harikrishna, Yokota Hiroki

Abstract excerpt

To investigate phenotypic and genotypic alterations before and after bone metastasis, we conducted genome-wide mRNA profiling and DNA exon sequencing of two cell lines (TMD and BMD) derived from a mouse xenograft model. TMD cells were harvested from the mammary fat pad after transfecting MDA-MB-231 breast cancer cells, while BMD cells were isolated from the metastasized bone. Compared to BMD cells, TMD cells...

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Source

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Identifiers

PMID: 28615627
DOI: 10.1038/s41598-017-03811-9
PMCID: PMC5471271

Genes

GRM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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