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Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response

1 Jun 2017

Abstract excerpt

PB1-F2 is a viral protein encoded by influenza A viruses (IAVs). PB1-F2 is implicated in virulence by triggering immune cell apoptosis and enhancing inflammation. To obtain an insight into the molecular mechanisms of PB1-F2-mediated virulence, we used the yeast two-hybrid approach to find new PB1-F2 cellular interactors. This allowed us to identify calcium-binding and coiled-coil domain 2 (CALCOCO2, also known as...

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PMID: 28613140
DOI: 10.1099/jgv.0.000782

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